Barely Significant
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Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.

Mediators Inflamm · 2015 · PMC4348606 · PMID 25788762

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showed a trendno p-value reported
Also in another study the SNP rs35829419 revealed a significant association with the increased IL-1 β levels and showed a trend to the lower levels of CRP in plasma [ 54 ].

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.