Umbilical cord blood and placental mercury, selenium and selenoprotein expression in relation to maternal fish consumption.

Expression of GPx1, GPx4 and SelP mRNAs were not statistically different between the group that ate no fish and the group that ate <12 oz/wk (not shown) or the group that ate ≥12 oz/wk, regardless of placental region, although GPx1 mRNA showed a trend toward higher expression in the ≥12 oz/wk group in tissue from the fetal side, both proximal to the umbilical cord (p-value 0.105) and peripheral (p-value 0.13).

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Selenoenzyme activity levels in placenta Cellular glutathione peroxidase and thioredoxin reductase activities were measured, with no fish consumption-dependent differences in any region of the placenta, although a slight trend toward higher GPx activity was seen in placenta from the fetal side proximal to the umbilical cord in samples from the high fish consumption group, consistent with the increase in GPx1 mRNA in this region ( Figure 4 ).

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