Gtl2 (–/+) teratomas expressed p53 at significantly lower levels compared with WT-induced teratomas, which showed a trend, although not significant, toward a negative correlation with teratoma weight (r = –0.6429, P = 0.069) ( Fig. 2C ).
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Deleting maternal Gtl2 leads to growth enhancement and decreased expression of stem cell markers in teratoma.
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