Early-life lead exposure recapitulates the selective loss of parvalbumin-positive GABAergic interneurons and subcortical dopamine system hyperactivity present in schizophrenia.

At PN50, the resulting blood Pb 2+ levels in these animals was 22.2±0.9 μg dl −1 ( n =47) for Pb 2+ exposed rats and 0.6±0.1 μg dl −1 ( n =64) for control rats, a difference that was highly significant ( P <0.0001).

also in 132,142 other papers

We found significantly higher concentrations of the DA metabolites DOPAC (208% increase; P =0.0009) and HVA (146% increase; P =0.016) in the striatum of Pb 2+ exposed rats relative to controls ( Figure 5b ), whereas DA ( P =0.089), DOPAC/DA ( P =0.099) and HVA/DA ( P =0.099) ratio did not reach statistical significance after adjusting for multiple comparisons ( Figure 5b ).

also in 111,027 other papers