Blood-brain barrier transport studies, aggregation, and molecular dynamics simulation of multiwalled carbon nanotube functionalized with fluorescein isothiocyanate.

Although a slight elevation of tight junction proteins (ZO-1) has been previously reported by Rotoli et al investigating the impairment of barrier function in Calu-3 monolayers, caused by MWCNT structures, the change did not reach statistical significance because of the variability of absolute protein expression levels in the different experiments. 40 The CellTiter-Glo ® luminescent cell viability assay (Promega) was used to determine the cytotoxicity of MWCNT–FITC.

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