Hypothermia modulates cytokine responses after neonatal rat hypoxic-ischemic injury and reduces brain damage.

At 72 hr post-HII, total lesion volumes showed a trend toward reduction in HT compared with NT pups (42%; p = .37) as did the penumbra (53%; p = .25) with little change in the ischemic core (16%; p = .77).

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Moreover, HT demonstrated a weak trend ( r 2 = .12) of increasing SDF-1 expression with an increase in penumbra size in HT pups ( Figure 6 ).

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