Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants.

CPT Pharmacometrics Syst Pharmacol · 2015 · PMC4360665 · PMID 26225230

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did not reach statistical significanceno p-value reported

The sirolimus CL int in pediatric liver microsomes tended to be lower compared with that in adult microsomes although this difference did not reach statistical significance most likely due to small sample size.

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