AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.

Increased β-oxidation in skeletal muscle following AAV8- Sirt1 treatment AAV8- Sirt1 mice showed a trend to accumulate less triglycerides in skeletal muscle than AAV8-Null mice ( Figure 5a ), suggesting that β-oxidation could be upregulated in this tissue following the treatment.

also in 53,322 other papers