HOMA, BMI, and Serum Leptin Levels Variations during Antiviral Treatment Suggest Virus-Related Insulin Resistance in Noncirrhotic, Nonobese, and Nondiabetic Chronic Hepatitis C Genotype 1 Patients.

However, when we assessed HOMA-IR variations during treatment on the basis of different kinetics of viral load decay, we found a significant reduction of HOMA-IR values at week 12 and a still but weakly significant reduction at week 48 from baseline in the EVR ( P = 0.033 and 0.048, resp.) but not in the non-EVR groups ( Table 4 ).

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