The correlation between NOTCH1 and IGF1R was also confirmed considering CLL patients only (p = 0.001), conversely, among cMBL the association between IGF1R expression and NOTCH1 mutation did not reach statistical significance, although a partial trend was demonstrated (data not shown).
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Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia.
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