The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.

ACS Chem Neurosci · 2015 · PMC4368042 · PMID 25587888

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a clear trendno p-value reported

For the size of the N -alkyl group in compounds 4a – 4d and 5a – 5d , we observed a clear trend showing that the longer and/or bulkier the N -alkyl group, the weaker the compounds’ potency for hM3Dq.

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