Potential biomarkers of fatigue in plasma metabolites In the first steps of the TCA cycle, the levels of organic acids in the fatigued group showed a slight reduction in comparison with those in the control group (citrate decreased by 12.1%, cis -aconitate by 7.7%, and isocitrate by 4.5%), while a subset of metabolites in the TCA cycle showed a trend toward overcompensation (2-oxoglutarate increased by 11.2%, succinate by 15.7%, fumarate by 27.0%, and malate by 24.6%) ( Fig. 5 ).
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Potential biomarkers of fatigue identified by plasma metabolome analysis in rats.
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