Primary screening for cervical cancer based on high-risk human papillomavirus (HPV) detection and HPV 16 and HPV 18 genotyping, in comparison to cytology.

PLoS One · 2015 · PMC4368762 · PMID 25793281

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did not reach statistical significanceno p-value reported

At the threshold of CIN3+ HPV testing had a sensitivity of 100% (95% CI 76.8%–100.0%), which was higher than the sensitivity of cytology [ASCUS+: 64.3% (95% CI 35.1%–87.2%)] but the difference did not reach statistical significance.

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marginally significantno p-value reported

By combining genotyping with cytology, testing positive for HPV16 or ASCUS+ cytology, as well as testing positive for HPV16 or HPV18 or ASCUS+ cytology had a markedly higher sensitivity of 75.6% (95% CI 65.4%–88.8%) and 92.6% (95% CI 91.8%–93.5%) respectively than ASCUS+ alone, the former being marginally significant and the latter being clearly significant and the highest among all test combinations.

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