The results revealed that, bufothionine showed a trend toward up-regulating the expressions of p53 (at the low, medium and high concentration corresponding P values were respectively 0.142,0.0257 and 0.0162), caspase-3 ( P = 0.246, 0.0267 and 0.0236), cyto-c ( P = 0.276, 0.0343 and 0.0429), Bid ( P = 0.0125, 0.0395 and 0.0132) and Bax ( P = 0.563, 0.0492 and 0.0357) in a dose-dependent manner, down-regulating the level of Bcl-2 ( P = 0.0232, 0.0178 and 0.0464), but had no significant effects on caspase-9 ( P = 0.253, 0.147 and 0.287).
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Bufothionine induced the mitochondria-mediated apoptosis in H22 liver tumor and acute liver injury.
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