Barely Significant
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Nutritional aspects of children and adolescents with epidermolysis bullosa: literature review.

An Bras Dermatol · 2015 · PMC4371671 · PMID 25830992

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quite significantno p-value reported
Despite the lack of information on the quantification of cutaneous protein loss in patients with EB, it is supposed to be quite significant, which reduces the possibility of maintaining a positive nitrogen balance. 6 The protein requirement is calculated using the offer of 115-200% of the estimated average requirement according to the Recommended Dietary Allowances (RDA), a component of the DRI, for the respective chronological age. 13 Regarding micronutrients, there are no specific guidelines that advise on their intake for patients with EB, making the conduct, in these case, empirical. 10 Micronutrient deficiencies in these patients result from losses through the skin, chronic inflammation and inadequate intake.

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