Effect of Puumala hantavirus infection on human umbilical vein endothelial cell hemostatic function: platelet interactions, increased tissue factor expression and fibrinolysis regulator release.

However, this hypothesis is merely based on a statistical trend observed in wells with the cells incubated with BPL inactivated virus.

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Interestingly, our experiment showed a trend to increased number of platelets bound to the BPL-inactivated virus treated cultures, suggesting active replication was unnecessary and inactivated virus, bound to the cell surface, might also bind to integrins present on platelets.

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