Results from a large cohort of US veterans showed that men with diabetes had a borderline significant reduced risk of stomach cancer (adjusted relative risk = 0.95, 95% CI, 0.89–1.02), and this association was more pronounced in black veterans (adjusted relative risk = 0.85, 95% CI, 0.75–0.96). 18 The same trend of significant inverse association was also found in a case–control study in northern I
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Population-based cohort studies of type 2 diabetes and stomach cancer risk in Chinese men and women.
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When examining the exposure as duration of diabetes prior to baseline, we did find a suggestion of an increased risk of stomach cancer for individuals diagnosed with T2DM ≥5 years prior to baseline, particularly for the traditionally low-risk groups for stomach cancer of never smokers, and individuals without a history of gastritis, but after adjustment for potential confounders these associations did not reach statistical significance ( Table S4 ).