CyclinD3 , Ki67 , and PCNA mRNAs were strikingly upregulated in the Ablation+CTGF cohort, in agreement with the highly significant increase in β-cell proliferation.
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Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice.
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The sentences
Ex vivo incubation with rhCTGF upregulated endogenous CTGF expression and other genes involved in TGF-β signaling; Itgα5 and Mmp2 showed a trend in increased expression.