T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease.

A negative correlation trend between Aβ1-42 and T 1ρ was observed in controls and MCI subjects, while in AD patients this correlation showed a positive trend.

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However, WM T 1ρ in MCI subjects and both GM T 1ρ and WM T 1ρ in AD patients showed an increasing trend with age ( Fig. 3 ).

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On the other hand, correlation between P-tau and T 1ρ showed a negative trend both in MCI subjects and AD patients. 4 Discussion In the current study, significantly higher WM T 1ρ and GM T 1ρ in MTL in brain of AD was observed compared to that of controls, which is in agreement with the previous studies ( Haris et al., 2011 ; Borthakur et al., 2008 ).

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