CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779.

Br J Pharmacol · 2015 · PMC4376459 · PMID 25425280

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showed a trendno p-value reported

It is also possible that some of the other residues such as Y308 7.43 , which showed a trend towards decreased sensitivity to TAK-779 in chemotaxis assays (Figure 4 B, Table 2 ), may make significant contributions to the TAK-779 binding pocket, with additional experimentation.

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