USE is unlikely to be useful in terms of altering the clinical decision of whether to perform FNAC for nodules that are already very suspicious for malignancy or completely benign on conventional US. Another potential role for USE is for nodules with non-diagnostic or indeterminate cytological results on FNAC (e.g., cellular atypia of indeterminate significance), which affects approximately 30% of FNACs [ 61 – 63 ].
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