SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.

Genes Dev · 2015 · PMC4378198 · PMID 25792601

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showed a trendno p-value reported

In addition, in 15 paired samples of breast carcinomas and adjacent tissues, the protein levels of JFK, IL-8, and MMP9 were found to be higher in tumor tissues than in adjacent tissues, and the level of ING4 generally showed a trend inverse with that of JFK ( Fig. 7 C, top).

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