Tumor circulating DNA profiling in xenografted mice exposed to intermittent hypoxia.

Conversely, DNA modification percentages in the Ttl locus were equivalent for the XenoRA and XenoIH groups in tissue genomic DNA (mean cirDNA modification: XenoRA= 84.4 ± 5.6 %, XenoIH= 83.6 ± 6.5 %; p=0.796), but DNA modification in PBC genomic DNA was higher in XenoRA than in XenoIH (mean cirDNA modifications: XenoRA= 86.5 ± 16.8 %, XenoIH= 42.1 ± 13.3 %; p=0.709) in concordance with plasma cirDNA results, though the evident differences did not reach statistical significance (Figure 5D ).

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