For trial 205.458 alone, the shift tables for absence/presence of VPB runs off treatment/on treatment showed a trend for differences between the lower (1.25, 2.5 μg) and higher (5 μg) tiotropium Respimat® doses.
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Cardiac safety of tiotropium in patients with COPD: a combined analysis of Holter-ECG data from four randomised clinical trials.
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