Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference is associated with lactate evolution in the hemodynamic resuscitation process in early septic shock.

The odds ratio of an adequate lactate clearance was 0.10 (95% confidence interval = 0.03 to 0.3, P <0.001) in those patients with an elevated P cva CO 2 /C av O 2 ratio (≥1.4), whereas it did not reach statistical significance ( P = 0.1) for those patients with a P cva CO 2 gap ≥6 mmHg.

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