An adjuvanted, tetravalent dengue virus purified inactivated vaccine candidate induces long-lasting and protective antibody responses against dengue challenge in rhesus macaques.

Although both challenge viruses induced RNAemia in each of the vaccine groups, duration was reduced compared with that in the control group, and this reduction was significant or nearly significant for the AS03 A and AS03 B groups after DENV-1 challenge ( P = 0.024 and P = 0.053, respectively; both approximately 3 days decrease).

also in 3,349 other papers