P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.

Oncogene · 2015 · PMC4387124 · PMID 25284585

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closest p · 1.4× alpha

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boldest claim

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showed a trendp =0.07so close (0.05 < p ≤ 0.1)

P-REX1-high cells were significantly more sensitive to GDC-0941 ( p =0.01), and showed a trend towards sensitivity to PI-103 ( p =0.07) compared to P-REX1-low cells ( Fig. 5G ).

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