As shown in Fig 4A , renal cortical MMP-9 protein tends to increase in the diabetic rats (0.473±0.175, n = 4) compared to age-matched controls (0.249±0.043, n = 4), but this difference did not reach statistical significance ( P = 0.13).
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Matrix metalloproteinase-9 expression is enhanced in renal parietal epithelial cells of zucker diabetic Fatty rats and is induced by albumin in in vitro primary parietal cell culture.
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