CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation.

The differences between mutant GFP-HIF-1α-S247A and wild-type GFP-HIF-1α plus D4476, although they did not reach statistical significance, indicate that modification of HIF-1α Ser247 may not be the sole involvement of CK1δ in HIF-1 regulation. 3.4 Inhibition of CK1δ-dependent phosphorylation of HIF-1α facilitates metabolic adaptation of cells to hypoxia To evaluate whether the enhanced HIF-1 heterodimerization caused by CK1δ inhibiti

also in 111,027 other papers