Physical Routes to Primitive Cells: An Experimental Model Based on the Spontaneous Entrapment of Enzymes inside Micrometer-Sized Liposomes.

The effect here is not so dramatic because we have supposed a low concentration factor (3×), but if a similar mechanism would increase the substrate concentration by a factor 10 or so—as it happens in conventional sub-micrometer vesicles [ 9 ]—one could observe a quite significant rate enhancement inside (few) vesicles.

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