However, further experiments with anandamide at 10 nmol/L (Ki for CB2R = ≥280 nmol/L [ 3 ]), showed a trend for a decrease in anandamide effect by antagonism of CB1R and not by blocking CB2R or TRPV1 ( Fig 3A ).
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High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets.
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