Multi-parametric MRI at 14T for muscular dystrophy mice treated with AAV vector-mediated gene therapy.

Comparing absolute isometric tetanic force between mdx mice, we found treatment with rAAV6.CK8.H3μDys resulted in a small improvement compared with untreated mdx mice, however differences did not reach statistical significance, and they were not significantly different than wild-type values ( Fig 5A ).

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While the ADC and MTR measurements may not have shown as much statistical significance in the ANOVA, it is still worth noting the values of the data collected for all the imaging modalities show a decreasing trend in the values observed with only one exception.

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