Hepatitis infection in the treatment of opioid dependence and abuse.

methadone, antidepressants, etc.) are not known, but such “drug-drug interactions” may be significant, and certain alternative medications such as kava-kava have been associated with the development of fulminant liver failure.

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While substantial, these differences did not reach statistical significance, possibly because of the small numbers of subjects involved and the low statistical power.

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