Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome.

The repeated measures (RM)- ANOVA yielded a significant main effect of genotype ( F (1,38) = 4.12; p = 0.049), with RTT mice falling from the dowel significantly earlier than wt controls (Figure 3 ), and a genotype by treatment interaction just missing significance ( F (1,38) = 3.77; p = 0.060).

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Post hoc comparisons by Tukey’s test on the genotype by treatment interaction showed a trend towards a reduction in the synaptic potentiation after TBS in vehicle-treated MeCP2-308 females with respect to vehicle-treated wt (Figure 5 ).

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