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Gelatin nanoparticle-mediated intranasal delivery of substance P protects against 6-hydroxydopamine-induced apoptosis: an in vitro and in vivo study.

Drug Des Devel Ther · 2015 · PMC4396575 · PMID 25897205

Europe PMCDOI
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showed a trendP >0.05actually significant
Meanwhile, the PD rats that received daily intranasal treatment with 75 μg or 100 μg of SP showed a significant decrease in the number of apomorphine-induced rotations when compared with hemiparkinsonian rats ( P <0.05), while PD rats that received 50 μg of SP per day intranasally showed a trend towards improvement ( P >0.05), indicating that the extent of the protective effect of SP against 6-OHDA-induced apoptosis has a positive relationship with the concentration of SP.

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