Evaluation of opioid modulation in major depressive disorder.

Neuropsychopharmacology · 2015 · PMC4397403 · PMID 25518754

Europe PMC DOI

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0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

nearly significantp =0.054so close (0.05 < p ≤ 0.1)

Following 7 days of treatment in subjects with MDD, a 1 : 1 ratio of BUP and SAM, the ratio associated with maximal antagonism of opioid effects, exhibited statistically significant improvement vs placebo in HAM-D17 total score ( p =0.032) and nearly significant improvement in Montgomery-Åsberg Depression Rating Scale (MADRS) total score ( p =0.054).

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