Altered theta oscillations and aberrant cortical excitatory activity in the 5XFAD model of Alzheimer's disease.

Neural Plast · 2015 · PMC4398951 · PMID 25922768

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a significant trendP = 0.090so close (0.05 < p ≤ 0.1)

For the total 48 h observation period, a significant trend was observed between controls and 5XFAD mice (−5.55 ± 5.77 versus −28.77 ± 10.56, df = 8, t = 1.928, P = 0.090, Figure 7(a) ); for nonmotor activity this change turned out to be significant (5.11 ± 4.88 versus −27.51 ± 8.99, df = 8, t = 3.189, P = 0.013, Figure 7(b) ).

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a statistical trendP = 0.095so close (0.05 < p ≤ 0.1)

For the total recording period (light and dark phase) and the dark phase there was a tendency of reduced theta frequency in 5XFAD mice (7.04 ± 0.28 Hz versus 6.50 ± 0.20 Hz, Figure 8(a) ; 6.77 ± 0.25 Hz versus 6.29 ± 0.23 Hz, Figure 8(c) ) with a statistical trend during the light phase (7.09 ± 0.26 Hz versus 6.48 ± 0.19 Hz, df = 8, t = 1.896, P = 0.095, Figure 8(b) ).

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