MMP-2 activity was very low in the control hearts, whereas it was significantly increased in the hearts containing grafted C2C12/GFP and C2C12/RLX cells ( P <0.01).We also observed a tendency of C2C12/RLX-grafted hearts to possess higher MMP-2 activity compared to the C2C12/GFP ones, although the differences did not reach statistical significance.
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Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling.
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