The analysis revealed a striking atrophic response to sciatic nerve resection both in the artificial muscle and in the underlying TA (Supplementary Fig S10 G–J), while the clenbuterol treatment showed only a modest, which did not reach statistical significance in both artificial and underlying muscles, possibly due to inadequate response time or concentration (Supplementary Fig S10 C–F); quantification obtained evaluating CSA average of the treated artificial and TA muscles in ten non-adjacent sections (Supplementary Fig S10 A and B).
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In vivo generation of a mature and functional artificial skeletal muscle.
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