Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.

Genes Dev · 2015 · PMC4403258 · PMID 25846796

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did not reach statistical significanceno p-value reported

Intriguingly, analysis of bones isolated from 12-wk-old OSX-Cre ; Hif-2 α fl/fl mice showed that despite lowered levels of OPG mRNA, only a modest increase in trabecular and endosteal osteoclast numbers was observed; however, these differences did not reach statistical significance ( Fig. 5 E,F).

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