Although none of the more modestly significant insulin sensitivity loci translated to T2D, rs7219451 and rs322394 nearly reached genome-wide significance.
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Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
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Subsequently, an enrichment analysis was performed among these variants to determine whether an excess of nominally significant values was observed.