A randomized Phase II study of oxaliplatin plus capecitabine versus irinotecan plus capecitabine as first-line treatment in 94 patients aged ≥70 years showed a 5.3-month difference in median OS in favor of the oxaliplatin regimen, although it did not reach statistical significance ( P =0.162). 10 In contrast, two trials found similar OS for oxaliplatin and irinotecan regimens.
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Oxaliplatin-based first-line chemotherapy is associated with improved overall survival compared to first-line treatment with irinotecan-based chemotherapy in patients with metastatic colorectal cancer - Results from a prospective cohort study.
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0.1620