Sleep-like behavior and 24-h rhythm disruption in the Tc1 mouse model of Down syndrome.

Comparison of wheel-running activity showed a trend towards a delay in the acrophase of wheel-running activity at the beginning of the dark phase for Tc1 animals, although this was not significant ( Fig. 2 a, wild-type acrophase at 22.00 ± 0.41 h and Tc1 at 20.96 ± 0.25 h, F 1,17 = 1.553, P = 0.230).

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