Although the minimal increase in CD4 + T cell proliferation in GFAPγR1Δ mice was reduced by IL-6 neutralization to approximately the level of CD4 + T cell proliferation in WT mice, the reduction did not reach statistical significance (Figure 7 B).
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Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis.
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