Lepr cre ; Angpt1 fl/GFP mice transplanted with wild-type bone marrow cells (Cre − → Lepr) showed a trend toward increased Evans blue extravasation but the effect was not statistically significant relative to control mice ( Figure 8A ).
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Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1.
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