A trend towards an increase of PDE3A-ir ICC area in small intestine of Spry4 KO mice did not reach statistical significance (n = 5–7 animals per group) while, the PDE3A-ir ICC area was significantly increased in Kit WT/K641E small intestine ( Fig 9 ).
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Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice.
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