hMSH6 SNP rs1042821 showed a significant trend (P trend <0.001) associating younger age at diagnosis (<50) in breast cancer cases in North Carolina [ 78 ]. hMSH6 Pro92Pro polymorphism (rs1800932) showed a protective effect for tumors in the colorectum and colon in patients with Swedish origin (n = 1103 for colon cancer, n = 637 for rectal cancer, and n = 436 for controls) with the rare allele being associated with increased levels of mRNA and ovarian aging [ 79 , 80 ].
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A study of molecular signals deregulating mismatch repair genes in prostate cancer compared to benign prostatic hyperplasia.
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