Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes.

Meta-analysis of IVGTT-derived quantitative traits showed a nominally significant association between the variant and reduced beta-cell responsiveness to glucose ( β = −0.1 mmol · kg −1 · min −1 ; 95% CI: −0.200.20 – −0.024; P = 0.01) assuming a dominant model of inheritance, but failed to replicate a previously reported association with area under the curve (AUC) for insulin.

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