Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1.

PLoS One · 2015 · PMC4423859 · PMID 25950680

Europe PMC DOI

hedged sentences

0.0683

closest p · 1.4× alpha

0.0900

boldest claim

The sentences

showed a trendP = 0.0683so close (0.05 < p ≤ 0.1)

The hiPSC line D1-iPSC4 showed a trend towards a higher susceptibility to allogeneic than autologous NK cells ( Fig 3A ) (specific lysis: P = 0.0683, ANOVA, P = 0.0326, H test) although NK cells of donor 1 surprisingly killed the autologous D1-iPSC4 cells even better than allogeneic hiPSCs ( Fig 3B ) (specific lysis: P = 0.0345, ANOVA).

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borderline significanceP = 0.09so close (0.05 < p ≤ 0.1)

The killing of D6-iPSC2 cells by NK cells of donor 5 appeared also to be reduced but only at borderline significance (panel D in S10 Fig ) (P = 0.09, t -test).

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