Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study.

Eur J Nucl Med Mol Imaging · 2015 · PMC4424277 · PMID 25893384

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0.1200

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0.1200

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did not reach statistical significancep = 0.12not close (p > 0.1)

The comparison between 11 C-AZD2184 retention in 18- to 24-month-old APPswe mice hippocampi (mean SUV = 0.108 ± 0.052) and in age-matched wt mice hippocampi (mean SUV = 0.070 ± 0.017) did not reach statistical significance ( p = 0.12) (Fig. 1 b). 11 C-AZD2184 retention in a combined cortical and hippocampal ROI was significantly higher in 18- to 24-month-old APPswe compared to wt mice ( p = 0.05).

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